Colon Cancer Tissue Microarray (TMA)

• Designed for examination of associations of markers with tumor stage, clinical outcome, and other clinico-pathologic variables in Stage I – IV (Data Manual).
  
  
• The TMA specimen set consists of
  • Invasive colon carcinoma
    - Four stages: N = 367
  • Normal colon epithelium
    - Adjacent to the cancer: N = 34
    - From diverticulitis patients with no cancer: N = 40
  • Adenomatous polyps, no cancer: N= 37
  • Controls
    - Normal non-colon tissues: N = 32
    - Cell lines: N = 48
  
  
• Four replicate TMA blocks are created from each case set
  • Four cores are taken from each case block, with one of those cores placed in each of four replicate array blocks.
  • Example of a Colon TMA map. Actual maps are supplied with the TMA shipment.
  
  
• The TMA was designed by NCI statisticians for high statistical power for comparisons of marker values:
  • Between colon cancers of different stages
  • Between colon cancers that recurred within a few years of diagnosis versus colon cancers that remained recurrence free.
  
  For example, there is 80% power to detect:
  • Difference in prevalence rate for a binary marker of about 0.30 between stage I and stage IV cancer
  • Difference in prevalence rate of about 0.35 between stage II colon cancers that recurred within 5 years versus those that did not recur within 5 years.
  
  
  Statistical Guidance reference.
  
  
• Information for invasive colon carcinoma cases:
  • Race, gender and age at diagnosis
  • Year of diagnosis
  • Primary site within colon
  • TNM stage, number of positive nodes and total examined
  • Initial treatment—only Y/N: chemotherapy, radiation, surgery
  • Histology, grade, lymphovascular invasion, status of margins
  • Recurrence status and time to recurrence
  • Vital status and time to death
  • Cancer status at last follow-up
  
  
• Information for adenomatous polyp cases:
  • Gender
  • Age at diagnosis
  • Year of diagnosis
  • Polyp type
  • Degree of dysplasia
  • Gross size of polyp
  
  

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For additional information, contact:

Cindy Mattingly
Information Management Services, Inc.
12501 Prosperity Drive, Suite 200
Silver Spring, MD 20904
301-680-9770
tissueresources@imsweb.com